Decreased Fasting Free Fatty Acids with L-Carnitine in Children with Carnitine Deficiency

MR in children with L-carnitine deficiency.

PURPOSE To describe the MR imaging findings in five children with proved L-carnitine deficiency. METHODS MR imaging studies (five without contrast, two with contrast) were obtained in five children (mean age, 9 years) who presented with stroke symptoms and who proved to have L-carnitine deficiency as established by serum levels. RESULTS In three of five patients, infarctions were confined t...

Combined therapy with PPARalpha agonist and L-carnitine rescues lipotoxic cardiomyopathy due to systemic carnitine deficiency.

OBJECTIVE Peroxisome proliferator-activated receptors (PPAR) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily and are key regulators of fatty acid oxidation (FAO) in the heart. Systemic carnitine deficiency (SCD) causes disorders of FAO and induces hypertrophic cardiomyopathy with lipid accumulation. We hypothesized that activation of PPARalpha ...

Free Fatty Acids Profiling in Response to Carnitine Synergize with Lutein in Diabetic Rats

BACKGROUND The objective of this study was to investigate the fatty acids profiling in diabetic rats induced by sterptozocine (STZ) and their response to administration of lutein and carnitine. MATERIALS AND METHODS Ninety male albino rats were divided into 6 groups as follows: Normal control. The remaining rats were injected i.p a single dose of STZ (65 mg /kg bw) for induction of diabetes. ...

Carnitine Serum Levels in Children with Iron Deficiency Anemia

Objective: To evaluate carnitine serum levels as a comorbidity in children with iron deficiency anemia. Patients and Methods: Fifty-four well nourished children (29 boys and 25 girls) with iron deficiency anemia were enrolled. Twenty-five healthy non-anemic ageand sexmatched children were included as a control group. For all anemic children and controls, we performed complete blood cell count, ...

O-12: Do Dietary L-Carnitine and Omega-3 Fatty Acids Affect on Ram